Microplastics and human health: a narrative review of current evidence, knowledge gaps, and future research directions
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Abstract
Microplastics (MPs) have become widespread in food, water, air, and various consumer products, raising concerns about their potential impact on human health. Although research on this topic has grown rapidly, existing evidence remains fragmented, and the extent of associated health risks is not well understood. This narrative review aims to synthesize current evidence on human exposure to MPs, their biological mechanisms, and potential health effects, while identifying key knowledge gaps and future research priorities. This narrative review synthesized recent findings from peer-reviewed studies published between 2015 and 2025. Literature was identified through major scientific databases and manual reference checks, focusing on exposure pathways, biological mechanisms, and possible health outcomes related to MPs. Because this review relies solely on previously published data, ethical approval was not required. The literature shows that humans are exposed to MPs primarily through ingestion and inhalation. Experimental studies indicate that MPs can cross epithelial barriers, induce oxidative stress, and provoke inflammatory responses, although human evidence remains limited. Potential health implications include gastrointestinal disturbances, respiratory irritation, and possible reproductive or metabolic effects. However, inconsistent detection methods and limited epidemiological data hinder clear risk assessment. While MPs may pose emerging health risks, substantial knowledge gaps remain. Future research should prioritize standardized analytical methods, realistic exposure assessments, and long-term human studies. Strengthening preventive policies and reducing plastic pollution will be essential to protect public health.
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Abbas, G., Ahmed, U., & Ahmad, M. A. (2025). Impact of Microplastics on Human Health: Risks, Diseases, and Affected Body Systems. Microplastics, 4(2), 23. https://doi.org/10.3390/microplastics4020023.
Adhikari, S., Kelkar, V., Kumar, R., & Halden, R. U. (2022). Methods and challenges in the detection of microplastics and nanoplastics: a mini‐review. Polymer International, 71(5), 543–551. https://doi.org/10.1002/pi.6348.
Amato-Lourenço, L. F., Carvalho-Oliveira, R., Júnior, G. R., dos Santos Galvão, L., Ando, R. A., & Mauad, T. (2021). Presence of airborne microplastics in human lung tissue. Journal of Hazardous Materials, 416, 126124. https://doi.org/10.1016/j.jhazmat.2021.126124.
Bhat, M. A. (2024). A comprehensive characterization of indoor ambient microplastics in households during the COVID-19 pandemic. Air Quality, Atmosphere & Health, 17(9), 2017–2033. https://doi.org/10.1007/s11869-024-01559-6.
Bora, S. S., Gogoi, R., Sharma, M. R., Anshu, Borah, M. P., Deka, P., Bora, J., Naorem, R. S., Das, J., & Teli, A. B. (2024). Microplastics and human health: unveiling the gut microbiome disruption and chronic disease risks. Frontiers in Cellular and Infection Microbiology, 14. https://doi.org/10.3389/fcimb.2024.1492759.
Calogero, A. E., Fiore, M., Giacone, F., Altomare, M., Asero, P., Ledda, C., Romeo, G., Mongioì, L. M., Copat, C., Giuffrida, M., Vicari, E., Sciacca, S., & Ferrante, M. (2021). Exposure to multiple metals/metalloids and human semen quality: A cross-sectional study. Ecotoxicology and Environmental Safety, 215, 112165. https://doi.org/10.1016/j.ecoenv.2021.112165.
Campanale, C., Massarelli, C., Savino, I., Locaputo, V., & Uricchio, V. F. (2020). A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health. International Journal of Environmental Research and Public Health, 17(4), 1212. https://doi.org/10.3390/ijerph17041212.
Cox, K. D., Covernton, G. A., Davies, H. L., Dower, J. F., Juanes, F., & Dudas, S. E. (2019). Human Consumption of Microplastics. Environmental Science & Technology, 53(12), 7068–7074. https://doi.org/10.1021/acs.est.9b01517.
Danopoulos, E., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of drinking water: A systematic review. PLOS ONE, 15(7), e0236838. https://doi.org/10.1371/journal.pone.0236838.
Dris, R., Gasperi, J., Mirande, C., Mandin, C., Guerrouache, M., Langlois, V., & Tassin, B. (2017). A first overview of textile fibers, including microplastics, in indoor and outdoor environments. Environmental Pollution, 221, 453–458. https://doi.org/10.1016/j.envpol.2016.12.013.
Dris, R., Gasperi, J., Rocher, V., Saad, M., Renault, N., & Tassin, B. (2015). Microplastic contamination in an urban area: a case study in Greater Paris. Environmental Chemistry, 12(5), 592–599. https://doi.org/10.1071/EN14167.
Enyoh, C. E., Shafea, L., Verla, A. W., Verla, E. N., Qingyue, W., Chowdhury, T., & Paredes, M. (2020). Microplastics Exposure Routes and Toxicity Studies to Ecosystems: An Overview. Environmental Analysis Health and Toxicology, 35(1), e2020004. https://doi.org/10.5620/eaht.e2020004.
Gimiliani, G. T., & Izar, G. (2022). Difficulties in Comparison Among Different Microplastic Studies: The Inconsistency of Results and Lack of Guide Values. Environmental Toxicology and Chemistry, 41(4), 820–821. https://doi.org/10.1002/etc.5237.
Guo, Y., Rong, M., Fan, Y., Teng, X., Jin, L., & Zhao, Y. (2025). The Presence of Microplastics in Human Semen and Their Associations with Semen Quality. Toxics, 13(7), 566. https://doi.org/10.3390/toxics13070566.
Han, J. H., & Kim, H. S. (2025). Microplastics in Cosmetics: Emerging Risks for Skin Health and the Environment. Cosmetics, 12(4), 171. https://doi.org/10.3390/cosmetics12040171.
Hirt, N., & Body-Malapel, M. (2020). Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature. Particle and Fibre Toxicology, 17(1), 57. https://doi.org/10.1186/s12989-020-00387-7.
Horvatits, T., Tamminga, M., Liu, B., Sebode, M., Carambia, A., Fischer, L., Püschel, K., Huber, S., & Fischer, E. K. (2022). Microplastics detected in cirrhotic liver tissue. EBioMedicine, 82, 104147. https://doi.org/10.1016/j.ebiom.2022.104147.
Hou, B., Wang, F., Liu, T., & Wang, Z. (2021). Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice. Journal of Hazardous Materials, 405, 124028. https://doi.org/10.1016/j.jhazmat.2020.124028.
Huang, M., Si, C., Qiu, C., & Wang, G. (2024). Microplastics analysis: from qualitative to quantitative. Environmental Science: Advances, 3(12), 1652–1668. https://doi.org/10.1039/D4VA00244J.
Ibrahim, Y. S., Tuan Anuar, S., Azmi, A. A., Wan Mohd Khalik, W. M. A., Lehata, S., Hamzah, S. R., Ismail, D., Ma, Z. F., Dzulkarnaen, A., Zakaria, Z., Mustaffa, N., Tuan Sharif, S. E., & Lee, Y. Y. (2021). Detection of microplastics in human colectomy specimens. JGH Open, 5(1), 116–121. https://doi.org/10.1002/jgh3.12457.
Islam, Md. Z., Zaman, S. U., Sami, N. I., Roy, S., Jeba, F., Islam, Md. S., & Salam, A. (2024). Human inhalation exposure assessment of the airborne microplastics from indoor deposited dusts during winter in Dhaka, Bangladesh. Heliyon, 10(16), e36449. https://doi.org/10.1016/j.heliyon.2024.e36449.
Jiao, X., Cao, Q., & Deng, Z. (2025). Microplastics and exercise: impacts on performance and physiological health. Frontiers in Sports and Active Living, 7. https://doi.org/10.3389/fspor.2025.1611255.
Kacprzak, S., & Tijing, L. D. (2022). Microplastics in indoor environment: Sources, mitigation and fate. Journal of Environmental Chemical Engineering, 10(2), 107359. https://doi.org/10.1016/j.jece.2022.107359.
Karami, A., Golieskardi, A., Keong Choo, C., Larat, V., Galloway, T. S., & Salamatinia, B. (2017). The presence of microplastics in commercial salts from different countries. Scientific Reports, 7(1), 46173. https://doi.org/10.1038/srep46173.
Kosuth, M., Mason, S. A., & Wattenberg, E. V. (2018). Anthropogenic contamination of tap water, beer, and sea salt. PLOS ONE, 13(4), e0194970. https://doi.org/10.1371/journal.pone.0194970.
Kwon, J.-H., Kim, J.-W., Pham, T. D., Tarafdar, A., Hong, S., Chun, S.-H., Lee, S.-H., Kang, D.-Y., Kim, J.-Y., Kim, S.-B., & Jung, J. (2020). Microplastics in Food: A Review on Analytical Methods and Challenges. International Journal of Environmental Research and Public Health, 17(18), 6710. https://doi.org/10.3390/ijerph17186710.
Lai, H., Liu, X., & Qu, M. (2022). Nanoplastics and Human Health: Hazard Identification and Biointerface. Nanomaterials, 12(8), 1298. https://doi.org/10.3390/nano12081298.
Lalrinfela, P., Vanlalsangi, R., Lalrinzuali, K., & Babu, P. J. (2024). Microplastics: Their effects on the environment, human health, and plant ecosystems. Environmental Pollution and Management, 1, 248–259. https://doi.org/10.1016/j.epm.2024.11.004.
Lazaridis, K. N., Koutsari, C., & Samsonraj, R. M. (2025). Microplastics and Nanoplastics and the Digestive System. Gastro Hep Advances, 4(8), 100694. https://doi.org/10.1016/j.gastha.2025.100694.
Lee, D.-W., Jung, J., Park, S., Lee, Y., Kim, J., Han, C., Kim, H.-C., Lee, J. H., & Hong, Y.-C. (2024). Microplastic particles in human blood and their association with coagulation markers. Scientific Reports, 14(1), 30419. https://doi.org/10.1038/s41598-024-81931-9.
Lee, Y., Cho, J., Sohn, J., & Kim, C. (2023). Health Effects of Microplastic Exposures: Current Issues and Perspectives in South Korea. Yonsei Medical Journal, 64(5), 301. https://doi.org/10.3349/ymj.2023.0048.
Li, Y., Chen, L., Zhou, N., Chen, Y., Ling, Z., & Xiang, P. (2024). Microplastics in the human body: A comprehensive review of exposure, distribution, migration mechanisms, and toxicity. Science of The Total Environment, 946, 174215. https://doi.org/10.1016/j.scitotenv.2024.174215.
Liu, S., Liu, X., Guo, J., Yang, R., Wang, H., Sun, Y., Chen, B., & Dong, R. (2023). The Association Between Microplastics and Microbiota in Placentas and Meconium: The First Evidence in Humans. Environmental Science & Technology, 57(46), 17774–17785. https://doi.org/10.1021/acs.est.2c04706.
Nouri, M., Massahi, T., & Hossini, H. (2025). Microplastics in human body: a narrative on routes of exposure to contamination and potential health effects. Environmental Pollutants and Bioavailability, 37(1). https://doi.org/10.1080/26395940.2025.2538535.
Okoffo, E. D., Donner, E., McGrath, S. P., Tscharke, B. J., O’Brien, J. W., O’Brien, S., Ribeiro, F., Burrows, S. D., Toapanta, T., Rauert, C., Samanipour, S., Mueller, J. F., & Thomas, K. V. (2021). Plastics in biosolids from 1950 to 2016: A function of global plastic production and consumption. Water Research, 201, 117367. https://doi.org/10.1016/j.watres.2021.117367.
Pironti, C., Notarstefano, V., Ricciardi, M., Motta, O., Giorgini, E., & Montano, L. (2022). First Evidence of Microplastics in Human Urine, a Preliminary Study of Intake in the Human Body. Toxics, 11(1), 40. https://doi.org/10.3390/toxics11010040.
Prata, J. C., da Costa, J. P., Lopes, I., Duarte, A. C., & Rocha-Santos, T. (2020). Environmental exposure to microplastics: An overview on possible human health effects. Science of The Total Environment, 702, 134455. https://doi.org/10.1016/j.scitotenv.2019.134455.
Praveena, S. M., & Laohaprapanon, S. (2021). Quality assessment for methodological aspects of microplastics analysis in bottled water – A critical review. Food Control, 130, 108285. https://doi.org/10.1016/j.foodcont.2021.108285.
Pulusu, V. S., Chilamula, S., Holkunde, A., Gunturi, R., Vidiyala, P., & Anekalla, T. R. (2025). Microplastics in the Environment: Sources, Detection Techniques, and Analytical Challenges. OALib, 12(07), 1–33. https://doi.org/10.4236/oalib.1113697.
Ragusa, A., Svelato, A., Santacroce, C., Catalano, P., Notarstefano, V., Carnevali, O., Papa, F., Rongioletti, M. C. A., Baiocco, F., Draghi, S., D’Amore, E., Rinaldo, D., Matta, M., & Giorgini, E. (2021). Plasticenta: First evidence of microplastics in human placenta. Environment International, 146, 106274. https://doi.org/10.1016/j.envint.2020.106274.
Rahman, A., Sarkar, A., Yadav, O. P., Achari, G., & Slobodnik, J. (2021). Potential human health risks due to environmental exposure to nano- and microplastics and knowledge gaps: A scoping review. Science of The Total Environment, 757, 143872. https://doi.org/10.1016/j.scitotenv.2020.143872.
Raju K. Chalannavar, Avinash A. Kamble, Ravindra B. Malabadi, Divakar MS, Swathi, Kishore S. Karamchand, Kiran P. Kolkar, Somayyeh Moramazi, Antonia Neidilê Ribeiro Munhoz, & Karen Viviana Castaño Coronado. (2025). Microplastics: Detection methods-An update. World Journal of Advanced Research and Reviews, 26(2), 2809–2824. https://doi.org/10.30574/wjarr.2025.26.2.1715.
Saha, S. C., & Saha, G. (2024). Effect of microplastics deposition on human lung airways: A review with computational benefits and challenges. Heliyon, 10(2), e24355. https://doi.org/10.1016/j.heliyon.2024.e24355.
Schymanski, D., Goldbeck, C., Humpf, H.-U., & Fürst, P. (2018). Analysis of microplastics in water by micro-Raman spectroscopy: Release of plastic particles from different packaging into mineral water. Water Research, 129, 154–162. https://doi.org/10.1016/j.watres.2017.11.011.
Sharma, P., Sharma, P., & Abhishek, K. (2024). Sampling, separation, and characterization methodology for quantification of microplastic from the environment. Journal of Hazardous Materials Advances, 14, 100416. https://doi.org/10.1016/j.hazadv.2024.100416.
Statista Research Department. (2025). Plastic Waste Worldwide - Statistics & Facts. Statista Research Department. https://www.statista.com/topics/5401/global-plastic-waste/.
Turroni, S., Wright, S., Rampelli, S., Brigidi, P., Zinzani, P. L., & Candela, M. (2021). Microplastics shape the ecology of the human gastrointestinal intestinal tract. Current Opinion in Toxicology, 28, 32–37. https://doi.org/10.1016/j.cotox.2021.09.006.
Virtanen, H. E., Jørgensen, N., & Toppari, J. (2017). Semen quality in the 21st century. Nature Reviews Urology, 14(2), 120–130. https://doi.org/10.1038/nrurol.2016.261.
Wang, C., Zhao, J., & Xing, B. (2021). Environmental source, fate, and toxicity of microplastics. Journal of Hazardous Materials, 407, 124357. https://doi.org/10.1016/j.jhazmat.2020.124357.
Wang, W., & Wang, J. (2018). Comparative evaluation of sorption kinetics and isotherms of pyrene onto microplastics. Chemosphere, 193, 567–573. https://doi.org/10.1016/j.chemosphere.2017.11.078.
Wibowo, A. T., Nugrahapraja, H., Wahyuono, R. A., Islami, I., Haekal, M. H., Fardiansyah, Y., Sugiyo, P. W. W., Putro, Y. K., Fauzia, F. N., Santoso, H., Götz, F., Tangahu, B. V., & Luqman, A. (2021). Microplastic Contamination in the Human Gastrointestinal Tract and Daily Consumables Associated with an Indonesian Farming Community. Sustainability, 13(22), 12840. https://doi.org/10.3390/su132212840.
Winiarska, E., Jutel, M., & Zemelka-Wiacek, M. (2024). The potential impact of nano- and microplastics on human health: Understanding human health risks. Environmental Research, 251, 118535. https://doi.org/10.1016/j.envres.2024.118535.
Xu, M., Halimu, G., Zhang, Q., Song, Y., Fu, X., Li, Y., Li, Y., & Zhang, H. (2019). Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell. Science of The Total Environment, 694, 133794. https://doi.org/10.1016/j.scitotenv.2019.133794.
Yang, Y., Xie, E., Du, Z., Peng, Z., Han, Z., Li, L., Zhao, R., Qin, Y., Xue, M., Li, F., Hua, K., & Yang, X. (2023). Detection of Various Microplastics in Patients Undergoing Cardiac Surgery. Environmental Science & Technology, 57(30), 10911–10918. https://doi.org/10.1021/acs.est.2c07179.
Zhang, W., Chen, Q., & Walker, T. R. (2025). Key methodological priorities for establishing a microplastics detection laboratory. Journal of Hazardous Materials: Plastics, 1, 100004. https://doi.org/10.1016/j.hazmp.2025.100004.
Zhao, X., Zhou, Y., Liang, C., Song, J., Yu, S., Liao, G., Zou, P., Tang, K. H. D., & Wu, C. (2023). Airborne microplastics: Occurrence, sources, fate, risks and mitigation. Science of The Total Environment, 858, 159943. https://doi.org/10.1016/j.scitotenv.2022.159943.
Zhou, L., Ran, L., He, Y., & Huang, Y. (2025). Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review). Molecular Medicine Reports, 31(4), 1–12. https://doi.org/10.3892/mmr.2025.13463.
Zurub, R. E., Cariaco, Y., Wade, M. G., & Bainbridge, S. A. (2024). Microplastics exposure: implications for human fertility, pregnancy and child health. Frontiers in Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1330396.